Hyperandrogenemia is implicated in both the metabolic and reproductive morbidities of polycystic ovary syndrome
- 주제(키워드) Hyperandrogenemia , metabolic morbidity , reproductive morbidity , polycystic ovary syndrome
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE INC
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000091146
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.fertnstert.2013.11.027
초록/요약
Objective: To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities. Design: Cross-sectional case-control study. Setting: Academic medical setting. Patient(s): A total of 1,062 women with PCOS and 1,887 women without PCOS. Intervention(s): None. Main Outcome Measure(s): Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels. Result(s): A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis. Conclusion(s): A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS. (C) 2014 by American Society for Reproductive Medicine.
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