Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2011
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000092307
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/np1006718
초록/요약
A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented). © 2011 The American Chemical Society and American Society of Pharmacognosy.
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