Syndecans play dual roles as cell adhesion receptors and docking receptors
- 주제(키워드) Adhesion receptor , Cell adhesion , Docking receptor , Extracellular matrix , Signal transduction , Syndecan
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier BV
- 발행년도 2012
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000093916
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.febslet.2012.05.037
초록/요약
Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown Copyright © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved.
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