Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit
- 등재 SCIE, SCOPUS
- 발행기관 Royal Society of Chemistry
- 발행년도 2013
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000094920
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c2mb25419k
초록/요약
A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined. © 2013 The Royal Society of Chemistry.
more