2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks
- 주제(키워드) 2 cys peroxiredoxin , epidermal growth factor , mitogen activated protein kinase , nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1 , peroxidase , peroxiredoxin , peroxiredoxin 1 , peroxiredoxin 2 , phosphatidylinositol 3 , 4 , 5 trisphosphate 3 phosphatase , platelet derived growth factor B , tumor necrosis factor alpha , unclassified drug , vasculotropin receptor 2 , acetylation , apoptosis , cell differentiation , cell growth , cell proliferation , cell transformation , enzyme activity , enzyme inactivation , human , lipid peroxidation , mammal cell , nonhuman , oxidative stress , priority journal , protein phosphorylation , review , signal transduction
- 등재 SCOPUS
- 발행기관 Hindaw Publishing Corporation
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000096528
- 본문언어 영어
- Published As http://dx.doi.org/10.1155/2014/715867
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H2O2. In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase. These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.
more