Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment
- 주제(키워드) D1 receptor , D2 receptor , reversal , dynamic foraging task , mouse , reinforcement learning
- 등재 SCIE, SCOPUS
- 발행기관 FRONTIERS RESEARCH FOUNDATION
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000114475
- 본문언어 영어
- Published As http://dx.doi.org/10.3389/fnbeh.2014.00368
초록/요약
In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas DI R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment.
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