The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
- 주제(키워드) Biological activity , Biosynthetic pathway , FK506 , FK506 analogs , Genetic engineering , Production improvement
- 등재 SCIE, SCOPUS
- 발행기관 Springer Verlag
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000119274
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10295-015-1677-7
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized. © 2015 Society for Industrial Microbiology and Biotechnology
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