The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment
- 주제(키워드) Cortical thickness , Motor intentional disorder , Subcortical vascular cognitive impairment , Tract-based spatial statistics
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
- 발행년도 2015
- URI http://www.dcollection.net/handler/ewha/000000120174
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s00415-015-7946-6
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A “Pinch-Grip” apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients. © 2015 Springer-Verlag Berlin Heidelberg
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