Marinopyrones A-D, α-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae
- 주제(키워드) Anti-inflammatory activity , Nocardiopsis sp. , Streptomonospora sp. , α-Pyrone
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000126612
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.tetlet.2016.03.084
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively, were isolated from marine sediments collected off shore near La Jolla, California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 1D and 2D NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an α-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC50 value of 13μM. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophilic genus Streptomonospora. © 2016 Elsevier Ltd.
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