Minireview: Syndecans and their crucial roles during tissue regeneration
- 주제(키워드) Extracellular matrix , Growth factor , Syndecan
- 등재 SCIE, SCOPUS
- 발행기관 Wiley Blackwell
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000135310
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/1873-3468.12280
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors are not only ubiquitous in mammalian tissues, regulating cell adhesion, migration, proliferation, and differentiation through independent signaling but also working alongside other receptors. Their importance is highlighted by an ability to interact with a diverse array of ligands, including extracellular matrix glycoproteins, growth factors, morphogens, and cytokines that are important regulators of regeneration. We also discuss the potential for syndecans to regulate stem cell properties, and suggest that understanding these proteoglycans is relevant to exploiting cell, tissue, and materials technologies. © 2016 Federation of European Biochemical Societies.
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