An overview of rapamycin: from discovery to future perspectives
- 주제(키워드) Biological activity , Biosynthesis , Mechanism of action , Production enhancement , Rapamycin
- 등재 SCIE, SCOPUS
- 발행기관 Springer Verlag
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000139579
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10295-016-1834-7
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities. The core structure of rapamycin is derived from (4R,5R)-4,5-dihydrocyclohex-1-ene-carboxylic acid that is extended by polyketide synthase. The resulting linear polyketide chain is cyclized by incorporating pipecolate and further decorated by post-PKS modification enzymes. Herein, we review the discovery and biological activities of rapamycin as well as its mechanism of action, mechanistic target, biosynthesis, and regulation. In addition, we introduce the many efforts directed at enhancing the production of rapamycin and generating diverse analogs and also explore future perspectives in rapamycin research. This review will also emphasize the remarkable pilot studies on the biosynthesis and production improvement of rapamycin by Dr. Demain, one of the world’s distinguished scientists in industrial microbiology and biotechnology. © 2016 Society for Industrial Microbiology and Biotechnology
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