Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.
- 주제(키워드) BACE1 inhibitor , Lodopyridone , Marine natural products , Saccharomonospora
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2017
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000145617
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.bmcl.2017.05.035
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1). © 2017 Elsevier Ltd
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