Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus
- 주제(키워드) Cognitive function , Grey matter , Obesity , Overweight , Type 2 diabetes mellitus , White matter
- 등재 SCIE, SCOPUS
- 발행기관 Springer Verlag
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000146968
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s00125-017-4266-7
초록/요약
Aims/hypothesis: Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. Methods: This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. Results: Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = −2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = −2.12, p for interaction = 0.03), while normal-weight participants did not. Conclusions/interpretation: The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants. © 2017, Springer-Verlag Berlin Heidelberg.
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