One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(I) acetylides
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Ryu, Jae-Sang] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea; Ewha Womans Univ, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000150089
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c7ra12889d
초록/요약
One-pot three-component reactions using copper(I) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.
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