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Long-term immunogenicity of an initial booster dose of an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC) and the safety and immunogenicity of a second JE-VC booster dose in children previously vaccinated with an inactivated, mouse brain-derived Japanese encephalitis vaccine

  • 주제(키워드) Japanese encephalitis , Vaccine , Vero cells , Clinical trial , Children
  • 주제(기타) Immunology; Medicine, Research & Experimental
  • 설명문(일반) [Yun, Ki Wook; Lee, Hoan Jong; Park, Ji Young] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea; [Cho, Hye-Kyung] Gachon Univ, Coll Med, Dept Pediat, Incheon, South Korea; [Kim, Yae-Jean] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea; [Kim, Kyung-Hyo] Ewha Womans Univ, Sch Med, Dept Pediat, Seoul, South Korea; [Kim, Nam Hee] Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Pediat, Goyang, South Korea; [Hong, Young Jin] Inha Univ, Coll Med, Dept Pediat, Incheon, South Korea; [Kim, Dong Ho] Korea Canc Ctr Hosp, Dept Pediat, Seoul, South Korea; [Kim, Hwang Min] Yonsei Univ, Wonju Coll Med, Dept Pediat, Wonju, South Korea; [Cha, Sung-Ho] Kyung Hee Univ, Dept Pediat, Coll Med, Seoul, South Korea; [Park, Ji Young] Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Pediat, Chang Won, South Korea
  • 등재 SCIE, SCOPUS
  • 발행기관 ELSEVIER SCI LTD
  • 발행년도 2018
  • URI http://www.dcollection.net/handler/ewha/000000151434
  • 본문언어 영어
  • Published As http://dx.doi.org/10.1015/j.vaccine.2018.01.075

초록/요약

Background: This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. Method: In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial. All subjects were subcutaneously vaccinated once for the booster immunization with Boryung Cell Culture Japanese Encephalitis Vaccine (R) (JE-VC). Result: Approximately 4 years after the 1st booster dose of JE-VC, the seroprotection rate (SPR) and geometric mean titer (GMT) of the neutralizing antibody were 100% and 1113.8, respectively. In children primed and given a 1st booster dose of JE-MB, the SPR and GMT were 88.5% and 56.3, respectively. After the 2nd booster dose of JE-VC, all participants primed and given a 1st booster dose of either JE-MB or JE-VC were seroprotective against JE virus. The GMT of the neutralizing antibody was higher in children primed and given a 1st booster dose of JE-VC (8144.1) than in those primed and given a 1st booster dose of JE-MB (942.5) after the vaccination (p < 0.001). In addition, the 2nd booster dose of JE-VC showed a good safety profile with no serious vaccine-related adverse events. Conclusion: The 1st booster dose of JE-VC and JE-MB showed long-term immunogenicity of at least 4 years, and the 2nd booster dose of JE-VC showed a good safety and immunogenicity profile in children primed and given a 1st booster dose of either JE-VC or JE-MB. (C) 2018 Elsevier Ltd. All rights reserved.

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