Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial
- 주제(키워드) <bold>cognitive impairment</bold> , <bold>executive function</bold> , <bold>short-term memory</bold> , <bold>subjective</bold> , <bold>subjective memory complaint</bold> , <bold>Tremella fuciformis</bold>
- 주제(기타) Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
- 설명문(일반) [Ban, Soonhyun; Lee, Suji L.; Park, Shinwon; Kim, Jieun E.] Ewha Womans Univ, Div Convergence, Dept Brain & Cognit Sci, Scranton Coll, Int Educ Bldg 609,52 Ewhayeodae Gil, Seoul 03760, South Korea; [Jeong, Hyeonseok S.] Catholic Univ Korea, Incheon St Marys Hosp, Dept Radiol, Coll Med, Seoul, South Korea; [Lim, Soo Mee; Hong, Young Sun] Ewha Womans Univ, Sch Med, Dept Radiol, Seoul, South Korea
- 발행기관 MARY ANN LIEBERT, INC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151488
- 본문언어 영어
- Published As http://dx.doi.org/10.1089/jmf.2017.4063
초록/요약
The efficacy and safety of Tremella fuciformis (TF) as a nutritional supplement were assessed in individuals with subjective cognitive impairment (SCI). Seventy-five individuals with SCI were enrolled in an 8-week, randomized, double-blind, placebo-controlled trial of TF (600mg/day, n=30 or 1200mg/day, n=30) or placebo (n=15). The primary outcome measure was changes in total scores of the subjective memory complaint questionnaire. The secondary outcome measures were changes in performance on short-term memory and executive functions, which were assessed using standardized cognitive tests. In addition, voxel-based morphometry was performed to examine the effects of TF on changes in gray matter volume. The individuals in the TF group showed greater improvements in the total scores on the subjective memory complaint questionnaire compared with those in the placebo group. There were also significantly greater improvements in short-term memory and executive functions in the TF group relative to the placebo group. Exploratory analysis demonstrated that there were significant group-by-visit interactions on the left precuneus, right supramarginal gyrus, right middle frontal gyrus, and right postcentral gyrus at corrected P<.05. Overall frequency of adverse events did not differ among high-dose TF (40.4%), low-dose TF (35.1%), and placebo groups (41.4%). The current findings suggest that TF could be safely administered to relieve subjective memory complaints and enhance cognition in individuals with SCI.
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