Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016
- 주제(키워드) Helicobacter pylori , Korea , prevalence
- 주제(기타) Gastroenterology & Hepatology; Microbiology
- 설명문(일반) [Lee, Jeong Hoon; Choi, Kee Don; Jung, Hwoon-Yong] Univ Ulsan, Dept Gastroenterol, Coll Med, Asan Med Ctr, Seoul, South Korea; [Baik, Gwang Ho] Hallym Univ, Dept Internal Med, Coll Med, Chunchon, South Korea; [Park, Jong Kyu] Univ Ulsan, Dept Internal Med, Coll Med, Gangneung Asan Hosp, Kangnung, South Korea; [Kim, Sung Soo] Catholic Univ Korea, Uijongbu St Marys Hosp, Dept Internal Med, Uijongbu, South Korea; [Kim, Byung-Wook] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med, Incheon, South Korea; [Hong, Su Jin] Soonchunhyang Univ, Dept Internal Med, Coll Med, Bucheon, South Korea; [Lim, Hyun] Hallym Univ, Dept Internal Med, Coll Med, Anyang, South Korea; [Shin, Cheol Min] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; [Lee, Si Hyung] Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; [Jeon, Seong Woo] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; [Kim, Ji Hyun] Inje Univ, Dept Internal Med, Coll Med, Busan, South Korea; [Choi, Cheol Woong] Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan, South Korea; [Jung, Hye-Kyung] Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Jie-Hyun] Yonsei Univ, Dept Internal Med, Coll Med, Gangnam Severance Hosp, Seoul, South Korea; [Choi, Suck Chei] Wonkwang Univ, Dept Internal Med, Sch Med, Iksan, South Korea; [Choi, Suck Chei] Wonkwang Univ, Digest Dis Res Inst, Sch Med, Iksan, South Korea; [Cho, Jin Woong] Presbyterian Med Ctr, Dept Internal Med, Jeonju, South Korea; [Lee, Wan Sik] Chonnam Natl Univ, Dept Internal Med, Sch Med, Gwangju, South Korea; [Na, Soo-Young] Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; [Sung, Jae Kyu] Chungnam Natl Univ, Dept Internal Med, Sch Med, Daejeon, South Korea; [Song, Kyung Ho] Konyang Univ, Dept Internal Med, Coll Med, Daejeon, South Korea; [Chung, Jun-Won] Gil Med Ctr, Gachon Grad Sch Med, Dept Internal Med, Incheon, South Korea; [Yun, Sung-Cheol] Univ Ulsan, Dept Clin Epidemiol & Biostat, Coll Med, Asan Med Ctr, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151510
- 본문언어 영어
- Published As http://dx.doi.org/10.1111/hel.12463
초록/요약
BackgroundThe Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H.pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H.pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. MethodsWe planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H.pylori serum IgG using a chemiluminescent enzyme immunoassay. ResultsWe analyzed 4917 samples (4917/4920=99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H.pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H.pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P<.0001). The H.pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40years (38.1% in those aged 30-39years and 57.7% in those aged 40-49years) and was lower in city residents than in noncity residents at all ages. ConclusionsHelicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H.pylori-related policies.
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