Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Jung, Youngae; Kim, Nami; Hwang, Geum-Sook] Korea Basic Sci Inst, Western Seoul Ctr, Integrated Metabol Res Grp, Seoul, South Korea; [Jung, Youngae; Kang, Sang Won] Ewha Womans Univ, Dept Life Sci, Seoul, South Korea; [Cho, Youngjin; Oh, Ii-Young] Seoul Natl Univ, Div Cardiol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; [Choi, Eue-Keun] Seoul Natl Univ Hosp, Div Cardiol, Dept Internal Med, Seoul, South Korea; [Hwang, Geum-Sook] Ewha Womans Univ, Dept Chem & Nanosci, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 PUBLIC LIBRARY SCIENCE
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151515
- 본문언어 영어
- Published As http://dx.doi.org/10.1371/journal.pone.0196709
초록/요약
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its incidence is increasing worldwide. One method used to restore sinus rhythm is direct current cardioversion (DCCV). Despite the high success rate of DCCV, AF typically recurs within the first 2 weeks. However, our understanding of the pathophysiology of AF recurrence, incidence, and progression are highly limited. Lipidomic profiling was applied to identify altered lipids in plasma from patients with AF using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis. Partial least-squares discriminant analysis revealed a clear separation between AF patients and healthy controls. The levels of several lipid species, including fatty acids and phospholipids, were different between AF patients and healthy controls, indicating that oxidative stress and inflammation are associated with the pathogenesis of AF. Similar patterns were also detected between recurrent and non-recurrent AF patients. These results suggest that the elevated saturated fatty acid and reduced polyunsaturated fatty acid levels in AF patients may be associated with enhanced inflammation and that free fatty acid levels may play a crucial role in the development and progression of AF.
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