Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete
- 주제(키워드) farm soil , actinomycete , Streptomyces sp. , cyclic peptide , antimetastatic
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 설명문(일반) [Kwon, Yun; Byun, Woong Sub; Bae, Munhyung; Shin, Jongheon; Lee, Sang Kook; Oh, Dong-Chan] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; [Kim, Byung-Yong] ChunLab Inc, JW Tower, Seoul 06725, South Korea; [Song, Myoung Chong; Yoon, Yeo Joon] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151557
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/molecules23061266
초록/요약
LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (1 and 2), each containing two piperazic acid units and a formyl group at their N-terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess D-leucine, D-threonine, D-valine, and S-piperazic acid based on the advanced Marfey's method and a GITC (2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231).
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