Multicenter Retrospective Analysis of Clinical Characteristics, Treatment Patterns, and Outcomes in Very Elderly Patients with Diffuse Large B-Cell Lymphoma: The Korean Cancer Study Group LY16-01
- 주제(키워드) Diffuse large B-cell lymphoma , Aged , Infection
- 주제(기타) Oncology
- 설명문(일반) [Choi, Jung Hye] Hanyang Univ, Dept Internal Med, Guri Hosp, Coll Med, Guri, South Korea; [Kim, Tae Min] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Kim, Hyo Jung] Hallym Univ, Coll Med, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; [Koh, Sung Ae] Yeungnam Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; [Mun, Yeung-Chul] Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Kang, Hye Jin] Korea Canc Ctr Hosp, Korea Inst Radiol & Med Sci, Dept Internal Med, Seoul, South Korea; [Jung, Yun Hwa] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Shim, Hyeok] Wonkwang Univ, Dept Internal Med, Sch Med, Iksan, South Korea; [Chong, So Young] CHA Univ, Dept Internal Med, CHA Bundang Med Ctr, Seongnam, South Korea; [Sun, Der-Sheng] Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Internal Med, Uijongbu, South Korea; [Lee, Soonil] Dankook Univ, Coll Med, Dankook Univ Hosp, Dept Internal Med, Cheonan, South Korea; [Park, Byeong Bae] Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Kwon, Jung Hye] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Internal Med, Seoul, South Korea; [Nam, Seung-Hyun] Vet Hlth Serv Med Ctr, Dept Internal Med, Seoul, South Korea; [Yi, Jun Ho] Chung Ang Univ Hosp, Dept Internal Med, Seoul, South Korea; [Yuh, Young Jin] Inje Univ Sanggye Paik Hosp, Dept Internal Med, Seoul, South Korea; [Jin, Jong-Youl] Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Internal Med, Bucheon, South Korea; [Han, Jae Joon] Kyung Hee Univ, Dept Internal Med, Devis Hematol Oncol, Sch Med, Seoul, South Korea; [Kim, Seok-Hyun] Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Internal Med, Sch Med, Chang Won, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN CANCER ASSOCIATION
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151587
- 본문언어 영어
- Published As http://dx.doi.org/10.4143/crt.2017.172
초록/요약
Purpose The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data. Materials and Methods This multicenter retrospective study was conducted to investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years who were diagnosed with DLBCL at 19 institutions in Korea between 2005 and 2016. Results A total of 194 patients were identified (median age, 83.3 years). Of these, 114 patients had an age-adjusted International Prognostic Index (aaIPI) score of 2-3 and 48 had a Charlson index score of 4 or more. R-CHOP was given in 124 cases, R-CVP in 13 cases, other chemotherapy in 17 cases, radiation alone in nine cases, and surgery alone in two cases. Twenty-nine patients did not undergo any treatment. The median number of chemotherapy cycles was three. Only 37 patients completed the planned treatment cycles. The overall response rate from 105 evaluable patients was 90.5% (complete response, 41.9%). Twenty-nine patients died due to treatment-related toxicities (TRT). Thirteen patients died due to TRT after the first cycle. Median overall survival was 14.0 months. The main causes of death were disease progression (30.8%) and TRT (27.1%). In multivariate analysis, overall survival was affected by aaIPI, hypoalbuminemia, elevated creatinine, and treatment. Conclusion Age itself should not be a contraindication to treatment. However, since elderly patients show higher rates of TRT due to infection, careful monitoring and dose modification of chemotherapeutic agents is needed.
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