High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis
- 주제(키워드) Miliary tuberculosis , neutrophil-lymphocyte ratio (NLR)
- 주제(기타) Respiratory System
- 설명문(일반) [Han, Yeji; Kim, Soo Jung; Lee, Su Hwan; Ryu, Yon Ju; Chang, Jung Hyun; Lee, Jin Hwa] Ewha Womans Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Sim, Yun Su] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; [Shim, Sung Shin; Kim, Yookyung] Ewha Womans Univ, Coll Med, Dept Radiol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AME PUBL CO
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151624
- 본문언어 영어
- Published As http://dx.doi.org/10.21037/jtd.2017.12.65
초록/요약
Background: It is difficult to predict the prognosis of miliary tuberculosis (TB). We hypothesized that blood neutrophil-lymphocyte ratio (NLR) is an indicator of inflammatory status to reflect independent prognostic significance in patients with miliary TB. The aim of this study is to investigate the relationship between NLR and outcome in miliary TB. Methods: We retrospectively collected data from patients diagnosed with miliary TB in a tertiary referral hospital between January 1995 and January 2016. Results: A total of 96 patients were enrolled. Seventeen patients (18%) died during hospitalization due to miliary TB, and 9 (9%) died additionally during the 1-year follow-up period. Eighteen patients (19%) were diagnosed with acute respiratory distress syndrome (ARDS). In multiple logistic regression analyses, increased NLR was associated with ARDS [adjusted odds ratio, 1.15; 95% confidence interval (CI), 1.03-1.28]. By multivariate Cox regression analysis with adjustment of known prognostic factors including age, sex, body mass index, serum aspartate aminotransferase (AST), and hemoglobin, NLR was an independent predictor of in-hospital mortality [adjusted hazard ratio (aHR), 1.08; 95% CI, 1.03-1.13] and 1-year mortality (aHR, 1.08; 95% CI, 1.05-1.12). Conclusions: Pre-treatment NLR at admission may be a useful biomarker for mortality and development of ARDS in patients with miliary TB.
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