The effect of small or diminutive adenomas at baseline colonoscopy on the risk of developing metachronous advanced colorectal neoplasia: KASID multicenter study
- 주제(키워드) Diminutive adenoma , Metachronous colorectal neoplasia , Small adenoma , Surveillance
- 주제(기타) Gastroenterology & Hepatology
- 설명문(일반) [Moon, Chang Mo; Jung, Sung-Ae] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Eun, Chang Soo] Hanyang Univ, Dept Internal Med, Guri Hosp, Guri, South Korea; [Park, Jae Jun] Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Seo, Geom Seog] Wonkwang Univ, Digest Dis Res Inst, Dept Internal Med, Coll Med, Iksan, South Korea; [Cha, Jae Myung] Kyung Hee Univ, Dept Internal Med, Kyung Hee Univ Hosp Gang Dong, Sch Med, Seoul, South Korea; [Park, Sung Chul] Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea; [Chun, Jaeyoung] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Chun, Jaeyoung] Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; [Lee, Hyun Jung] Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Jung, Yunho] Soonchunhyang Univ, Cheonan Hosp, Dept Internal Med, Coll Med, Cheonan, South Korea; [Boo, Sun-Jin] Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; [Kim, Jin Oh] Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Joo, Young-Eun] Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; [Park, Dong Il] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, 108 Pyung Dong, Seoul 110746, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE INC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151797
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.dld.2018.04.001
초록/요약
Background: The clinical significance of diminutive or small adenomas remains ill defined. Aims: We evaluated the clinical impact of diminutive or small adenomas at baseline on the risk of developing metachronous advanced colorectal neoplasia (CRN). Methods: This multicenter, retrospective cohort study included 2252 patients with 1 or more colorectal adenomas at baseline and subsequent follow-up colonoscopy. Baseline colonoscopy findings were classified into 5 groups: 1 or 2 tubular adenomas (TAs) (<10 mm); 3-10 diminutive TAs (<= 5 mm); 3-10 TAs, including 1 or 2 small adenomas (6-10 mm); 3-10 TAs, including 3 or more small adenomas; and advanced adenoma. Results: In multivariate analysis, after adjusting for possible confounding variables (age at baseline, sex, body mass index, smoking habits, family history of colorectal cancer, regular use of aspirin or NSAIDs, and adenoma location), 3-10 TAs including 3 or more small adenomas (hazard ratio [HR] = 2.36, p = 0.034) and advanced adenoma (HR = 2.14, p < 0.001) were independent predictors for the risk of developing metachronous advanced CRN. However, 3-10 diminutive TAs or 3-10 TAs, including 1 or 2 small adenomas, were not associated with this outcome. Conclusions: Multiplicity of diminutive TAs, without advanced lesions, showed no clinical significance for risk of developing metachronous advanced CRN. (C) 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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