Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice
- 주제(기타) Biochemistry & Molecular Biology; Medicine, Research & Experimental
- 설명문(일반) [Choi, Yunsik; Lee, Sanghyuk; Kim, Kapyoul; Lee, Charles] Ewha Womans Univ, Dept Life Sci, Seoul, South Korea; [Kim, Soo-Hyun; Chung, Yeun-Jun] Catholic Univ Korea, Coll Med, Precis Med Res Ctr, Dept Microbiol,IRCGP, Seoul, South Korea; [Lee, Charles] Jackson Lab Genom Med, Farmington, CT USA
- 발행기관 NATURE PUBLISHING GROUP
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155686
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s12276-018-0115-0
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient's own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.
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