Proteogenomic Characterization of Human Early-Onset Gastric Cancer
- 주제(키워드) cancer subtypes , correlation between mRNA and protein abundance changes , correlation between mutation and phosphorylation , diffuse gastric cancer , proteogenomics , somatic nonsynonymous mutations
- 등재 SCIE, SCOPUS
- OA유형 Bronze
- 발행기관 Cell Press
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000155688
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.ccell.2018.12.003
- PubMed https://pubmed.ncbi.nlm.nih.gov/30645970
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data. © 2018 Elsevier Inc.
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