Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea
- 주제(키워드) Clostridium infections , Colitis , ulcerative , Polymerase chain reaction , Prevalence
- 등재 SCOPUS, KCI등재
- 발행기관 Korean Association for the Study of Intestinal Diseases
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155864
- 본문언어 영어
- Published As http://dx.doi.org/10.5217/ir.2018.16.2.267
초록/요약
Background/Aims: Clostridium difficile infection (CDI) has been reported to be a cause of flare-ups in patients with ulcerative colitis (UC). We evaluated the prevalence and clinical outcomes of CDI in patients with UC hospitalized for flare-ups. Methods: This was a prospective, multicenter study including 7 academic teaching hospitals in Korea. All consecutive patients with UC admitted for disease flare-up were enrolled. We detected the presence of CDI by using enzyme immunoassay, real-time polymerase chain reaction (RT-PCR) for toxin genes, and sigmoidoscopy. Results: Eighty-one consecutive patients with UC were enrolled from January 2014 to December 2015. Among 81 patients, 8 (9.9%) were diagnosed with CDI. Most of the cases were identified by RT-PCR. Enzyme immunoassay was positive in 3 of 8 patients, and only 1 had typical endoscopic findings of pseudomembranous colitis. There were no differences in demographic data, length of hospital stay, or colectomy rate between patients with and without CDI. Conclusions: CDI was not a rare cause of flare-up in patients with UC in Korea. However, CDI did not appear to affect the course of UC flare-up in Korean patients. RT-PCR was sensitive in detecting CDI and can be considered a diagnostic tool in patients with UC flare-up. ©2018. Korean Association for the Study of Intestinal Diseases.
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