Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence
- 주제(키워드) Alcohol dependence , Caudate nucleus , Carbohydrate-deficient transferrin , Structural magnetic resonance imaging , Semi-automated segmentation , Brain volume
- 주제(기타) Psychology, Clinical; Substance Abuse; Psychiatry
- 설명문(일반) [Park, Shinwon; Jung, Jiyoung J.; Kang, Ilhyang; Lee, Suji L.; Ma, Jiyoung; Kim, Jungyoon; Cho, Han Byul; Lim, Soo Mee; Kim, Jieun E.] Ewha Womans Univ, Ewha Brain Inst, Seoul, South Korea; [Park, Shinwon; Kang, Ilhyang; Lee, Suji L.; Kim, Jungyoon; Lim, Soo Mee; Kim, Jieun E.] Ewha Womans Univ, Ewha Brain Inst, Dept Brain & Cognit Sci, Seoul, South Korea; [Jung, Jiyoung J.] Dobong Community Addict Management Ctr, Seoul, South Korea; [Lee, Boung Chul] Hallym Univ, Hangang Sacred Heart Hosp, Dept Neuropsychiat, Seoul, South Korea; [Ma, Jiyoung] Seoul Natl Univ, Interdisciplinary Program Neurosci, Seoul, South Korea; [Cho, Han Byul] Univ Utah, Brain Inst, Salt Lake City, UT USA; [Jeong, Hyeonseok S.] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Radiol, Seoul, South Korea; [Lim, Soo Mee] Ewha Womans Univ, Sch Med, Dept Radiol, Seoul, South Korea; [Lim, Soo Mee] Ewha Womans Univ, Sch Med, Med Res Inst, Seoul, South Korea; [Hong, Young Sun] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; [Choi, Ihn-Geun] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Psychiat, Seoul, South Korea
- 등재 SCIE, SSCI, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155892
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s11469-017-9803-6
초록/요약
The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = - 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (beta = - 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.
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