Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study
- 주제(키워드) cigarette smoking , microbiota , gastrointestinal microbiome , 16S rRNA
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Lee, Su Hwan; Kim, Soo Jung; Lee, Jin Hwa] Ewha Womans Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Yun, Yeojun; Lee, Eun-Ju; Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07985, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Ctr Cohort Studies,Sch Med, Seoul 03181, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul 03181, South Korea; [Shin, Hocheol] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Family Med, Sch Med, Seoul 03181, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea
- 등재 SCOPUS
- 발행기관 MDPI
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155960
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm7090282
초록/요약
There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated the relationship between smoking status and the composition of gut microbiota. This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total of 758 men were selected and divided into three groups: never (n = 288), former (n = 267), and current smokers (n = 203). Among the three groups, there was no difference in alpha diversity, however, Jaccard-based beta diversity showed significant difference (p = 0.015). Pairwise permutational multivariate analysis of variance (PERMANOVA) tests between never and former smokers did not show a difference; however, there was significant difference between never and current smokers (p = 0.017) and between former and current smokers (p = 0.011). Weighted UniFrac-based beta diversity also showed significant difference among the three groups (p = 0.038), and pairwise PERMANOVA analysis of never and current smokers showed significant difference (p = 0.01). In the analysis of bacterial composition, current smokers had an increased proportion of the phylum Bacteroidetes with decreased Firmicutes and Proteobacteria compared with never smokers, whereas there were no differences between former and never smokers. In conclusion, gut microbiota composition of current smokers was significantly different from that of never smokers. Additionally, there was no difference in gut microbiota composition between never and former smokers.
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