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Development and clinical application of an evidence-based pharmaceutical care service algorithm in acute coronary syndrome

  • 주제(키워드) acute coronary syndrome , evidence-based practice , pharmaceutical care , service algorithm
  • 주제(기타) Pharmacology & Pharmacy
  • 설명문(일반) [Kang, J. E.; Choi, J. H.; Rhie, S. J.] Ewha Womans Univ, Grad Sch, Div Life & Pharmaceut Sci, Seoul, South Korea; [Kang, J. E.] Natl Med Ctr, Dept Pharm, Seoul, South Korea; [Yu, J. M.; Kim, S. A.; Lee, E. K.; Rhie, S. J.] Ewha Womans Univ, Mokdong Hosp, Dept Pharm, Seoul, South Korea; [Choi, J. H.] Konkuk Univ, Med Ctr, Dept Pharm, Seoul, South Korea; [Chung, I. -M.; Pyun, W. B.] Ewha Womans Univ, Mokdong Hosp, Sch Med, Div Cardiol, Seoul, South Korea; [Han, N. Y.; Oh, J. M.] Seoul Natl Univ, Coll Pharm, Seoul, South Korea; [Han, N. Y.; Oh, J. M.] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul, South Korea; [Yoon, J. -H.] Pusan Natl Univ, Coll Pharm, Busan, South Korea; [Rhie, S. J.] Ewha Womans Univ, Coll Pharm, Seoul, South Korea
  • 등재 SCIE, SCOPUS
  • 발행기관 WILEY
  • 발행년도 2018
  • URI http://www.dcollection.net/handler/ewha/000000156091
  • 본문언어 영어
  • Published As http://dx.doi.org/10.1111/jcpt.12665

초록/요약

What is known and objective: Drug therapies are critical for preventing secondary complications in acute coronary syndrome (ACS). The purpose of this study was to develop and apply a pharmaceutical care service (PCS) algorithm for ACS and confirm that it is applicable through a prospective clinical trial. Methods: The ACS-PCS algorithm was developed according to extant evidence-based treatment and pharmaceutical care guidelines. Quality assurance was conducted through two methods: literature comparison and expert panel evaluation. The literature comparison was used to compare the content of the algorithm with the referenced guidelines. Expert evaluations were conducted by nine experts for 75 questionnaire items. A trial was conducted to confirm its effectiveness. Seventy-nine patients were assigned to either the pharmacist-included multidisciplinary team care (MTC) group or the usual care (UC) group. The endpoints of the trial were the prescription rate of two important drugs, readmission, emergency room (ER) visit and mortality. Results and discussion: The main frame of the algorithm was structured with three tasks: medication reconciliation, medication optimization and transition of care. The contents and context of the algorithm were compliant with class I recommendations and the main service items from the evidence-based guidelines. Opinions from the expert panel were mostly positive. There were significant differences in beta-blocker prescription rates in the overall period (P=.013) and ER visits (four cases, 9.76%, P=.016) in the MTC group compared to the UC group, respectively. What is new and conclusion: We developed a PCS algorithm for ACS based on the contents of evidence-based drug therapy and the core concept of pharmacist services.

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