The Derived Neutrophil-to-Lymphocyte Ratio Is an Independent Prognostic Factor in Transplantation Ineligible Patients with Multiple Myeloma
- 주제(키워드) Inflammatory markers , Lymphocytes , Multiple myeloma , Neutrophils , Prognostic factors
- 주제(기타) Hematology
- 설명문(일반) [Lee, Gyeong-Won; Park, Sung Woo] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Inst Hlth Sci, Dept Internal Med,Coll Med, Jinju, South Korea; [Go, Se-Il; Kim, Hoon-Gu] Gyeongsang Natl Univ, Dept Internal Med, Changwon Hosp, Inst Hlth Sci,Coll Med, Chang Won, South Korea; [Kim, Min Kyoung; Hyun, Myung Soo] Yeungnam Univ, Coll Med, Dept Med, Daegu, South Korea; [Min, Chang-Ki] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Div Hematol, Seoul, South Korea; [Kwak, Jae-Yong] Chonbuk Natl Univ, Sch Med, Dept Internal Med, Jeonju, South Korea; [Bae, Sang-Byung] Soonchunhyang Univ Hosp, Dept Internal Med, Cheonan, South Korea; [Yoon, Sung-Soo] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Lee, Je-Jung] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Hwasun, South Korea; [Kim, Ki Hwan] Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul, South Korea; [Nam, Seung-Hyun] VHS Med Ctr, Dept Internal Med, Seoul, South Korea; [Mun, Yeung-Chul] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; [Kim, Hyo Jung] Hallym Univ, Coll Med, Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea; [Bae, Sung Hwa] Catholic Univ Daegu, Sch Med, Dept Internal Med, Daegu, South Korea; [Shin, Ho-Jin] Pusan Natl Univ Hosp, Med Res Inst, Dept Internal Med, Div Hematol Oncol,Sch Med, Busan, South Korea; [Lee, Jung-Hee] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Hematol, Seoul, South Korea; [Park, Joon Seong; Jeong, Seong Hyun] Ajou Univ, Sch Med, Dept Hematol Oncol, Suwon, South Korea; [Lee, Mark Hong] Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med, Seoul, South Korea; [Lee, Ho Sup] Kosin Univ, Coll Med, Dept Hematol Oncol, Busan, South Korea; [Park, Keon Woo] Dankook Univ, Coll Med, Dept Internal Med, Cheonan, South Korea; [Lee, Won-Sik; Lee, Sang Min] Inje Univ, Busan Paik Hosp, Dept Internal Med, Busan, South Korea; [Lee, Jeong-Ok] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam Si, Gyeonggi Do, South Korea; [Jo, Deog Yeon] Chungnam Natl Univ Hosp, Dept Hematol Oncol, Daejeon, South Korea; [Lim, Sung-Nam] Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; [Lee, Jae Hoon; Kim, Hawk] Gachon Univ, Coll Med, Gil Med Ctr, Div Hematol, Incheon, South Korea; [Cho, Do-Yeun] Konyang Univ Hosp, Dept Internal Med, Daejeon, South Korea; [Do, Young Rok] Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; [Kim, Jeong-A] Catholic Univ Korea, Coll Med, Dept Hematol, Seoul, South Korea; [Park, Seong Kyu] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Bucheon, South Korea; [Kim, Jin Seok; Kim, Soo-Jeong] Yonsei Univ, Coll Med, Severance Hosp, Div Hematol,Dept Internal Med, Seoul, South Korea; [Yi, Hyeon Gyu] Inha Univ, Sch Med, Inha Univ Hosp, Dept Internal Med, Incheon, South Korea; [Moon, Joon Ho] Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea; [Choi, Chul Won] Korea Univ, Coll Med, Guro Hosp, Dept Internal Med, Seoul, South Korea; [Kim, Sung-Hyun] Dong A Univ, Coll Med, Dong A Med Ctr, Dept Internal Med, Busan, South Korea; [Kim, Byung Soo] Korea Univ, Coll Med, Med Ctr, Dept Hematol, Seoul, South Korea; [Park, Moo-Rim; Shim, Hyeok] Wonkwang Univ, Med, Dept Internal Med, Iksan, South Korea; [Song, Moo-Kon] Hanyang Univ, Hanmaeum Changwon Hosp, Dept Hematooncol, Chang Won, South Korea; [Kim, Youngdoe] Janssen Korea, Med Affairs, Seoul, South Korea; [Kim, Kihyun] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 KARGER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156149
- 본문언어 영어
- Published As http://dx.doi.org/10.1159/000490488
초록/요약
Background: The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic marker in solid and hematological cancers. While the derived NLR (dNLR) was shown to be non-inferior to the NLR in large cohorts of patients with different cancer types, it has not been validated as a prognostic marker for multiple myeloma (MM) to date. Methods: Between May 22, 2011 and May 29, 2014, 176 patients with MM from 38 centers who were ineligible for autologous stem cell transplantation were analyzed. The dNLR was calculated using complete blood count differential data. The optimal dNLR cut-off value according to receiver operating characteristic analysis of overall survival (OS) was 1.51. All patients were treated with melphalan and prednisone combined with bortezomib. Results: The complete response rate was lower in the high dNLR group compared to the low dNLR group (7 vs. 26.1%, respectively; p= 0.0148); the corresponding 2-year OS rates were 72.2 and 84.7%, respectively (p= 0.0354). A high dNLR was an independent poor prognostic factor for OS (hazard ratio 2.217, 95% CI 1.015-4.842; p= 0.0458). Conclusion: The dNLR is a readily available and cheaply obtained parameter in clinical studies, and shows considerable potential as a new prognostic marker for transplantation-ineligible patients with MM.
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