CHA(2)DS(2)-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Yi, Jeong-Eun; Park, Junbeom] Ewha Womans Univ, Sch Med, Coll Med, Dept Cardiol, Seoul, South Korea; [Lee, Young Soo] Catholic Univ Daegu, Div Cardiol, Daegu, South Korea; [Choi, Eue-Keun; Cha, Myung-Jin] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Kim, Tae-Hoon; Uhm, Jae-Sun; Joung, Boyoung] Yonsei Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul, South Korea; [Park, Jin-Kyu] Hanyang Univ, Coll Med, Div Cardiol, Seoul, South Korea; [Lee, Jung-Myung; Kim, Jin-Bae] Kyung Hee Univ, Coll Med, Div Cardiol, Seoul, South Korea; [Kang, Ki-Woon] Eulji Univ Hosp, Div Cardiol, Daejeon, South Korea; [Shim, Jaemin] Korea Univ, Anam Hosp, Div Cardiol, Seoul, South Korea; [Kim, Jun] Univ Ulsan, Coll Med, Dept Internal Med, Seoul, South Korea; [Kim, Changsoo] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Park, Hyung Wook] Chonnam Natl Univ, Sch Med, Dept Cardiovasc Med, Gwangju, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 NATURE PUBLISHING GROUP
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156725
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-018-36185-7
초록/요약
Exercise intolerance among the clinical symptoms in patients with atrial fibrillation (AF) has usually been masked by their adjusted life style. We sought to assess the role of CHA(2)DS(2)-VASc score to predict exercise intolerance in asymptomatic AF patients, and further examine whether the relationship differs by age and gender. Among the 6,275 participants of the prospective Korean registry of the Comparison study of Drugs for symptom control and complication prevention of Atrial Fibrillation (CODE-AF), 1,080 AF patients who underwent exercise treadmill testing were studied. Exercise intolerance was defined as a peak exercise capacity of 7 metabolic equivalents (METs) or less, and the patients were divided into two groups for the analysis: <= 7 METs (n = 131) and >7 METs (n = 949). Patients with exercise intolerance had a significantly higher CHA(2)DS(2)-VASc score than those without (3.1 +/- 1.3 vs. 2.0 +/- 1.5, p < 0.0001). In the multivariate analysis, a higher CHA(2)DS(2)-VASc score (OR 1.54, 95% CI 1.31-1.81, p < 0.0001), corrected QT interval (OR 1.01, 95% CI 1.00-1.02, p = 0.026), and increased left atrial volume index (OR 1.02, 95% CI 1.01-1.03, p = 0.001) were found to be independent predictors of exercise intolerance. The impact of the CHA(2)DS(2)-VASc score on exercise intolerance was significant only in male patients aged < 65 years (OR 3.30, 95% CI 1.76-6.19, p < 0.0001). The CHA(2)DS(2)-VASc score may be a feasible risk assessment tool to predict exercise intolerance, especially in young and middle-aged male patients with asymptomatic AF.
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