Abrogation of the Circadian Nuclear Receptor REV-ERB alpha Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration
- 주제(키워드) 6-hydroxydoapmine , neurodegeneration , circadian clock , Parkinson's disease , REV-ERB alpha
- 주제(기타) Biochemistry & Molecular Biology; Cell Biology
- 설명문(일반) [Kim, Jeongah; Jang, Sangwon; Choi, Mijung; Choe, Han Kyoung; Kim, Kyungjin] Daegu Gyeongbuk Inst Sci & Technol, Dept Brain & Cognit Sci, Daegu 42988, South Korea; [Kim, Jeongah; Rhee, Kunsoo] Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 08826, South Korea; [Chung, Sooyoung] Ewha Womans Univ, Dept Brain & Cognit Sci, Scranton Coll, Seoul 03760, South Korea; [Choe, Youngshik; Choe, Han Kyoung; Kim, Kyungjin] Korea Brain Res Inst, Daegu 41068, South Korea; [Son, Gi Hoon] Korea Univ, Dept Biomed Sci, Coll Med, Seoul 02841, South Korea
- 관리정보기술 faculty
- 발행기관 KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156797
- 본문언어 영어
- Published As http://dx.doi.org/10.14348/molcells.2018.0201
초록/요약
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (DAergic) neurons, particularly in the substantia nigra (SN). Although circadian dysfunction has been suggested as one of the pathophysiological risk factors for PD, the exact molecular link between the circadian clock and PD remains largely unclear. We have recently demonstrated that REV-ERB alpha, a circadian nuclear receptor, serves as a key molecular link between the circadian and DAergic systems. It competitively cooperates with NURR1, another nuclear receptor required for the optimal development and function of DA neurons, to control DAergic gene transcription. Considering our previous findings, we hypothesize that REV-ERB alpha may have a role in the onset and/or progression of PD. In the present study, we therefore aimed to elucidate whether genetic abrogation of REV-ERB alpha affects PD-related phenotypes in a mouse model of PD produced by a unilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. REV-ERB alpha deficiency significantly exacerbated 6-OHDA-induced motor deficits as well as DAergic neuronal loss in the vertebral midbrain including the SN and the ventral tegmental area. The exacerbated DAergic degeneration likely involves neuroinflammation-mediated neurotoxicity. The Rev-erb alpha knockout mice showed prolonged microglial activation in the SN along with the overproduction of interleukin 1 beta, a pro-inflammatory cytokine, in response to 6-OHDA. In conclusion, the present study demonstrates for the first time that genetic abrogation of REV-ERB alpha can increase vulnerability of DAergic neurons to neurotoxic insults, such as 6-OHDA, thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression.
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