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The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study

  • 주제(키워드) cholecystectomy , microbiota , gastrointestinal microbiome , 16S rRNA
  • 주제(기타) Medicine, General & Internal
  • 설명문(일반) [Yoon, Won Jae; Yi, Sun Young] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul 07985, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul 03181, South Korea; [Park, Eunkyo; Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07985, South Korea; [Ryu, Seungho; Chang, Yoosoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Ctr Cohort Studies,Sch Med, Seoul 03181, South Korea; [Ryu, Seungho; Chang, Yoosoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Occupat & Environm Med, Seoul 03181, South Korea; [Shin, Hocheol] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Family Med, Sch Med, Seoul 03181, South Korea
  • 등재 SCIE, SCOPUS
  • OA유형 Green Published, gold, Green Submitted
  • 발행기관 MDPI
  • 발행년도 2019
  • URI http://www.dcollection.net/handler/ewha/000000159774
  • 본문언어 영어
  • Published As http://dx.doi.org/10.3390/jcm8010079
  • PubMed https://pubmed.ncbi.nlm.nih.gov/30641967

초록/요약

Cholecystectomy alters the bile flow into the intestine and the enterohepatic circulation of the bile acids; this may affect the gut microbiota. We assessed the gut microbiota composition of patients who had undergone cholecystectomy and compared with those who had not. From a cohort of 1463 adult participants who underwent comprehensive health screening examinations, 27 subjects who had undergone cholecystectomy (cholecystectomy group) and 81 age- and sex-matched subjects who had not (control group) were selected. Clinical parameters were collected and compared. Microbial composition was determined by 16S rRNA gene sequencing of DNA extracted from fecal samples. We evaluated differences in the overall microbial composition and in the abundance of taxa. The two groups were comparable with respect to clinical characteristics and laboratory results. The actual number of taxa observed in a sample (observed features) was significantly lower in the cholecystectomy group than in the control group (p = 0.042). The beta diversity of Jaccard distance index was significantly different between the two groups (p = 0.027). Blautia obeum and Veillonella parvula were more abundant in the cholecystectomy group. The difference in the diversity of the gut microbiota between the cholecystectomy and control groups was subtle. However, B. obeum and V. parvula, which have azoreductase activity, were more abundant in the cholecystectomy group. The impact of such changes in the gut microbiota on health remains to be determined.

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