Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
- 주제(키워드) 14-Membered macrolide , Combinatorial biosynthesis , Polyketide synthase , Post-polyketide synthase tailoring
- 등재 SCIE, SCOPUS
- OA유형 Bronze
- 발행기관 Springer Verlag
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159951
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10295-018-2095-4
- PubMed https://pubmed.ncbi.nlm.nih.gov/30415291
초록/요약
Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides. © 2018, Society for Industrial Microbiology and Biotechnology.
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