Donghaesulfins A and B, Dimeric Benz[a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.
- 주제(기타) Chemistry, Organic
- 설명문(일반) [Bae, Munhyung; An, Joon Soo; Bae, Eun Seo; Oh, Jedo; Park, So Hyun; Kwon, Yun; Lee, Sang Kook; Shin, Jongheon; Oh, Dong-Chan] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 08826, South Korea; [Lim, Yeonjung; Cho, Jang-Cheon] Inha Univ, Dept Biol Sci, Incheon 22212, South Korea; [Ban, Yeon Hee; Yoon, Yeo Joon] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159955
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.orglett.9b01057
- PubMed https://pubmed.ncbi.nlm.nih.gov/31033298
초록/요약
The chemical analysis of a Streptomyces strain, from a Korean volcanic island, discovered new benz[a]anthracene dimers linked by a thioether bond. The structures of donghaesulfins A and B (1 and 2) were elucidated by spectroscopic analysis including energy-dispersive X-ray. Their configurations were determined by ROESY NMR data, DP4 calculations, the modified Mosher's method, and ECD calculations. Donghaesulfins A (1) induced quinone reductase, whereas donghaesulfin B (2) displayed antiangiogenesis activity.
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