A Review of the Microbial Production of Bioactive Natural Products and Biologics
- 주제(키워드) natural products , biologics , biological activity , microbial cell factories , genetic engineering , combinatorial biosynthesis , production improvement
- 주제(기타) Microbiology
- 설명문(일반) [Pham, Janette, V; Yilma, Mariamawit A.; Feliz, Adriana; Majid, Murtadha T.; Maffetone, Nicholas; Walker, Jorge R.; Reynolds, Jared M.; Park, Sung Ryeol] Geisinger Commonwealth Sch Med, Scranton, PA 18510 USA; [Pham, Janette, V; Yilma, Mariamawit A.; Feliz, Adriana; Majid, Murtadha T.; Maffetone, Nicholas; Walker, Jorge R.; Reynolds, Jared M.; Park, Sung Ryeol] Baruch S Blumberg Inst, Doylestown, PA 18902 USA; [Kim, Eunji; Song, Myoung Chong; Yoon, Yeo Joon] Ewha Womans Univ, Dept Chem & Nanosci, Seoul, South Korea; [Cho, Hyo Je] Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Daegu, South Korea; [Park, Sung Ryeol] Nat Prod Discovery Inst, Doylestown, PA 18902 USA
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159956
- 본문언어 영어
- Published As http://dx.doi.org/10.3389/fmicb.2019.01404
- PubMed https://pubmed.ncbi.nlm.nih.gov/31281299
초록/요약
A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous medical agents with widely divergent chemical structures and biological activities, including antimicrobial, immunosuppressive, anticancer, and anti-inflammatory activities, many of which have been developed as treatments and have potential therapeutic applications for human diseases. Aside from natural products, the recent development of recombinant DNA technology has sparked the development of a wide array of biopharmaceutical products, such as recombinant proteins, offering significant advances in treating a broad spectrum of medical illnesses and conditions. Herein, we will introduce the structures and diverse biological activities of natural products and recombinant proteins that have been exploited as valuable molecules in medicine, agriculture and insect control. In addition, we will explore past and ongoing efforts along with achievements in the development of robust and promising microorganisms as cell factories to produce biologically active molecules. Furthermore, we will review multi-disciplinary and comprehensive engineering approaches directed at improving yields of microbial production of natural products and proteins and generating novel molecules. Throughout this article, we will suggest ways in which microbial-derived biologically active molecular entities and their analogs could continue to inspire the development of new therapeutic agents in academia and industry.
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