Population-based volume kinetics of crystalloids and colloids in healthy volunteers
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Yi, Jung-Min] Catholic Kwandong Univ, Int St Marys Hosp, Dept Anesthesiol & Pain Med, Incheon, South Korea; [Bang, Ji-Yeon; Cho, Changhun; Lee, Yong-Hun; Choi, Byung-Moon; Noh, Gyu-Jeong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Anesthesiol & Pain Med, Seoul, South Korea; [Choi, Bohyun] Kyung Hee Univ, Grad Sch, Dept Nursing, Seoul, South Korea; [Choi, Bohyun] Kyung Hee Univ, Coll Nursing Sci, Seoul, South Korea; [Lee, Eun-Kyung] Ewha Womans Univ, Dept Stat, Seoul, South Korea; [Noh, Gyu-Jeong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Clin Pharmacol & Therapeut, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 NATURE PUBLISHING GROUP
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000166046
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-019-55171-1
- PubMed https://pubmed.ncbi.nlm.nih.gov/31819122
초록/요약
We characterized the volume kinetics of crystalloid solutions (Ringer's lactate solution and 5% dextrose water) and colloid solutions (6% tetrastarch and 10% pentastarch) by nonlinear mixed-effects modeling in healthy volunteers. We also assessed whether the bioelectrical impedance analysis parameters are significant covariates for volume kinetic parameters. Twelve male volunteers were randomly allocated to four groups, and each group received the four fluid solutions in specified sequences, separated by 1-week intervals to avoid any carryover effects. Volunteers received 40 ml/kg Ringer's lactate solution, 20 ml/kg 5% dextrose water, 1000 ml 6% tetrastarch, and 1000 ml 10% pentastarch over 1 h. Arterial blood samples were collected to measure the hemoglobin concentration at different time points. Bioelectrical impedance spectroscopy (BIS, INBODY S10, InBody CO., LTD, Seoul, Korea) was also carried out at preset time points. In total, 671 hemoglobin-derived plasma dilution data points were used to determine the volume kinetic characteristics of each fluid. The changes in plasma dilution induced by administration of crystalloid and colloid solutions were well-described by the two-volume and one-volume models, respectively. Extracellular water was a significant covariate for the peripheral volume of distribution at baseline in the volume kinetic model of Ringer's lactate solution. When the same amount was administered, the colloid solutions had similar to 4 times more plasma expansion effect than did the crystalloid solutions. Starches with larger molecular weights maintained the volume expansion effect longer than those with smaller molecular weights.
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