Safety and Efficacy of a New Ultrathin Sirolimus-Eluting Stent with Abluminal Biodegradable Polymer in Real-World Practice
- 주제(키워드) Drug-eluting stents , Percutaneous coronary intervention , Prospective studies , Registries
- 주제(기타) Cardiac & Cardiovascular Systems
- 설명문(일반) [Youn, Young Jin; Lee, Jun-Won; Ahn, Sung Gyun; Lee, Seung-Hwan; Yoon, Junghan] Yonsei Univ, Wonju Severance Christian Hosp, Dept Internal Med, Div Cardiol,Wonju Coll Med, Wonju, South Korea; [Yoo, Sang-Yong] Univ Ulsan, Gangneung Asan Hosp, Dept Internal Med, Div Cardiol,Coll Med, Kangnung, South Korea; [Park, Jae Hyoung] Korea Univ, Anam Hosp, Cardiovasc Ctr, Dept Cardiol, Seoul, South Korea; [Choi, Woong Gil] Konkuk Univ, Coll Med, Dept Internal Med, Div Cardiol,Chungju Hosp, Chungju, South Korea; [Cho, Sungsoo] Dankook Univ, Coll Med, Dept Internal Med, Div Cardiovasc Med,Dankook Univ Hosp, Cheonan, South Korea; [Lim, Sang-Wook] CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Div Cardiol, Seongnam, South Korea; [Jang, Yang Soo] Ewha Womans Univ, Sch Med, Dept Internal Med, Div Cardiol,Mokdong Hosp, Seoul, South Korea; [Kwon, Ki Hwan] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea; [Lee, Nam Ho] Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Div Cardiol, Goyang, South Korea; [Doh, Joon Hyung] Gachon Univ, Gil Med Ctr, Dept Cardiol, Incheon, South Korea; [Kang, Woong Chol] Yonsei Univ, Severance Cardiovasc Hosp, Dept Internal Med, Div Cardiol,Coll Med, Seoul, South Korea; [Jeon, Dong Woon] Natl Hlth Insurance Serv Ilsan Hosp, Dept Internal Med, Div Cardiol, Goyang, South Korea; [Lee, Bong-Ki] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Dept Internal Med, Chunchon, South Korea; [Heo, Jung Ho] Kosin Univ, Gospel Hosp, Dept Internal Med, Div Cardiol, Busan, South Korea; [Hong, Bum-Kee] Yonsei Univ, Gangnam Severance Hosp, Heart Ctr, Div Cardiol,Coll Med, Seoul, South Korea; [Choi, Hyun-Hee] Hallym Univ, Chuncheon Sacred Heart Hosp, Cardiovasc Ctr, Div Cardiol,Coll Med, Chunchon, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, hybrid
- 발행기관 KOREAN SOC CARDIOLOGY
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169234
- 본문언어 영어
- Published As https://dx.doi.org/10.4070/kcj.2019.0258
- PubMed https://pubmed.ncbi.nlm.nih.gov/31960640
초록/요약
Background and Objectives: Recently, Genoss drug-eluting stent (DES)(TM) stent comprising cobalt-chromium platform with an ultrathin strut thickness, sirolimus, and an abluminal biodegradable polymer was developed. Owing to the lack of substantial evidence for the safety and efficacy of this stent, we report 12-month results of the Genoss DES (TM) stent. Methods: We analyzed subjects who were eligible for a 12-month follow-up from the ongoing Genoss DES (TM) registry, which is a prospective, single-arm, observational, multicenter trial to investigate the clinical outcomes after the successful Genoss DES (TM) stent implantation among all-comers. The primary endpoint was a device-oriented composite outcome, defined as cardiac death, target vessel-related myocardial infarction, and target lesion revascularization at 12-month follow-up. Results: Among 622 subjects, the mean age of subjects was 66.5 +/- 10.4 years, 70.6% were males, 67.5% had hypertension, and 38.3% had diabetes. The implanted stent number, diameter, and length per patient were 1.5 +/- 0.8, 3.1 +/- 0.4 mm, and 36.0 +/- 23.3 mm, respectively. At 12-month clinical follow-up, the primary endpoint occurred only in 4 (0.6%) subjects. Conclusions: The novel Genoss DES (TM) stent exhibited excellent safety and efficacy in real-world practice.
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