Oral health and gastrointestinal cancer: A nationwide cohort study
- 주제(키워드) gastrointestinal cancer , oral hygiene , periodontal disease
- 주제(기타) Dentistry, Oral Surgery & Medicine
- 설명문(일반) [Lee, Kijeong] Yonsei Univ, Severance Hosp, Dept Neurol, Dept Radiol,Coll Med, Seoul, South Korea; [Lee, Ji Sung] Univ Ulsan, Clin Res Ctr, Asan Med Ctr, Asan Inst Life Sci,Coll Med, Seoul, South Korea; [Kim, Jinkwon] Yonsei Univ, Yongin Severance Hosp, Dept Neurol, Coll Med, Seoul, South Korea; [Lee, Huisong] Ewha Womans Univ, Mokdong Hosp, Dept Surg, Coll Med, Seoul, South Korea; [Chang, Yoonkyung] Ewha Womans Univ, Mokdong Hosp, Dept Neurol, Coll Med, Seoul, South Korea; [Woo, Ho Geol; Song, Tae-Jin] Ewha Womans Univ, Seoul Hosp, Dept Neurol, Coll Med, 260 Gonghang Daero, Seoul 07804, South Korea; [Kim, Jin-Woo] Ewha Womans Univ, Coll Med, Dept Oral & Maxillofacial Surg, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169396
- 본문언어 영어
- Published As https://dx.doi.org/10.1111/jcpe.13304
- PubMed https://pubmed.ncbi.nlm.nih.gov/32385894
초록/요약
Aims Poor oral hygiene is closely associated with bacteraemia and systemic inflammation, which are known mediators of cancer development. We investigated the relationship between oral hygiene indicators and the risk of gastrointestinal cancer in a nationwide population-based cohort. Materials and Methods This study was conducted on data from 150,774 subjects from the Korean National Health Screening Cohort. The occurrence of gastrointestinal cancer was analysed according to the presence of periodontal disease and oral hygiene indicators: frequency of toothbrushing, dental visits for any reason, professional dental cleanings and number of missing teeth. Gastrointestinal cancer was defined using International Statistical Classification of Diseases-10 codes C15-C26. Results During a median 11.6 years of follow-up, the estimated 10-year event rate for gastrointestinal cancer was 6.76%. In a multivariable analysis, after adjusting for age, sex, income level, regular exercise, alcohol consumption, smoking status, body mass index, history of comorbidities, systolic blood pressure and laboratory findings, frequent toothbrushing (>= 3/day) was significantly associated with a reduced risk for gastrointestinal cancer (hazard ratio: 0.91, 95% confidence interval (0.86-0.96), p < .001, p for trend < .001). Conclusions Good oral hygiene behaviour, especially frequent toothbrushing, could be associated with a lower risk of gastrointestinal cancer.
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