Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Jung, Hye-Kyung; Tae, Chung Hyun; Lee, Hye-Ah] Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Lee, Hyuk] Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea; [Choi, Kee Don; Jung, Hwoon-Yong] Univ Ulsan, Dept Gastroenterol, Asan Med Ctr, Coll Med, Seoul, South Korea; [Park, Jun Chul] Yonsei Univ, Dept Internal Med, Inst Gastroenterol, Coll Med, Seoul, South Korea; [Kwon, Joong Goo] Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; [Choi, Yoon Jin] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Gyeonggi Do, South Korea; [Hong, Su Jin] Soonchunhyang Univ, Ctr Digest Dis, Coll Med, Bucheon, South Korea; [Hong, Su Jin] Soonchunhyang Univ, Res Inst, Coll Med, Bucheon, South Korea; [Sung, Jaekyu] Chungnam Natl Univ, Dept Internal Med, Chungnam Natl Univ Hosp, Coll Med, Daejeon, South Korea; [Chung, Woo Chul] Catholic Univ Korea, St Vincent Hosp, Dept Internal Med, Suwon, South Korea; [Kim, Ki Bae] Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; [Kim, Seung Young] Korea Univ, Div Gastroenterol, Dept Internal Med, Ansan Hosp, Seoul, South Korea; [Song, Kyung Ho] Konyang Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Daejeon, South Korea; [Park, Kyung Sik] Keimyung Univ, Dept Internal Med, Coll Med, Daegu, South Korea; [Jeon, Seong Woo] Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; [Kim, Byung-Wook] Catholic Univ Korea, Incheon St Marys Hosp, Dept Internal Med, Coll Med, Incheon, South Korea; [Ryu, Han Seung] Wonkwang Univ, Dept Internal Med, Sch Med, Iksan, South Korea; [Ryu, Han Seung] Wonkwang Univ, Digest Dis Res Inst, Sch Med, Iksan, South Korea; [Lee, Ok-Jae] Gyeongsang Natl Univ, Dept Internal Med, Coll Med, Jinju, South Korea; [Lee, Ok-Jae] Gyeongsang Natl Univ, Inst Hlth Sci, Jinju, South Korea; [Baik, Gwang Ho] Hallym Univ, Coll Med, Dept Internal Med, Chuncheon Sacred Heart Hosp, Chunchon, South Korea; [Kim, Yong Sung] Wonkwang Digest Dis Res Inst, Gunpo, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 PUBLIC LIBRARY SCIENCE
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169402
- 본문언어 영어
- Published As https://dx.doi.org/10.1371/journal.pone.0231456
- PubMed https://pubmed.ncbi.nlm.nih.gov/32275699
초록/요약
Using data from the real world to solve clinical questions that cannot be answered using data from clinical trials is attracting more attention. Clinical outcomes for patients with esophageal cancer in a real-world setting might be different from data in randomized controlled trials. This study aimed to provide real world data on treatment and prognosis in Korean patients with esophageal cancer. This retrospective cancer cohort included newly diagnosed cases of esophageal cancer at 19 tertiary hospitals between January 1, 2005 and December 31, 2017. Cancer staging was defined according to the 7th edition of the American Joint Committee on Cancer criteria. We identified 6,354 patients with newly diagnosed esophageal cancer (mean age: 64.9 +/- 9.0 years, 96.9% squamous cell carcinoma). The proportion of early esophageal cancer increased from 24.7% in 2005 to 37.2% in 2015 (p<0.001). Among all cases, surgery alone was 31.3%, followed by definitive concurrent chemoradiotherapy (CCRT) (27.0%), neoadjuvant therapy (12.4%), adjuvant therapy (11.1%), and endoscopic resection (5.8%). The 5-year overall survival rate was 45.7 +/- 0.7%. Endoscopic resection provided similar median survival relative to surgery for stage Ia cases. Among stage II-III cases, definitive CCRT was associated with poorer survival than neoadjuvant or adjuvant therapy, although there was no survival difference between neoadjuvant and adjuvant therapy. Early esophageal cancer is gradually becoming more common and endoscopic resection provided similar long-term survival relative to surgery. Surgery with combined therapy provided better survival in locally advanced esophageal cancer, relative to definitive CCRT.
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