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Altered functional connectivity in the fear network of firefighters with repeated traumatic stress

  • 주제(키워드) Firefighter , post-traumatic stress disorder , functional magnetic resonance imaging , functional connectivity , fear network
  • 주제(기타) Psychiatry
  • 설명문(일반) [Jeong, Hyeonseok] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Dept Radiol, Seoul, South Korea; [Park, Shinwon; Lee, Suji L.; Hong, Haejin; Ma, Jiyoung; Ha, Eunji; Kang, Ilhyang; Yoon, Sujung; Kim, Jungyoon; Lyoo, In Kyoon] Ewha Womans Univ, Ewha Brain Inst, 52 Ewhayeodaegil, Seoul 03760, South Korea; [Park, Shinwon; Lim, Soo Mee; Lee, Suji L.; Hong, Haejin; Ha, Eunji; Yoon, Sujung; Kim, Jieun E.; Kim, Jungyoon; Lyoo, In Kyoon] Ewha Womans Univ, Dept Brain & Cognit Sci, 52 Ewhayeodaegil, Seoul 03760, South Korea; [Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA; [Dager, Stephen R.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA; [Lim, Soo Mee] Ewha Womans Univ, Dept Radiol, Seoul, South Korea; [Hong, Young Sun] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; [Lee, Eun Hee] Green Cross Labs, Dept Lab Med, Yongin, South Korea; [Lyoo, In Kyoon] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Lyoo, In Kyoon] Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA
  • 등재 SSCI, SCOPUS
  • OA유형 Bronze
  • 발행기관 CAMBRIDGE UNIV PRESS
  • 발행년도 2019
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000171917
  • 본문언어 영어
  • Published As https://dx.doi.org/10.1192/bjp.2018.260
  • PubMed https://pubmed.ncbi.nlm.nih.gov/30477594

초록/요약

Background Firefighters are routinely exposed to various traumatic events and often experience a range of trauma-related symptoms. Although these repeated traumatic exposures rarely progress to the development of post-traumatic stress disorder, firefighters are still considered to be a vulnerable population with regard to trauma. Aims To investigate how the human brain responds to or compensates for the repeated experience of traumatic stress. Method We included 98 healthy firefighters with repeated traumatic experiences but without any diagnosis of mental illness and 98 non-firefighter healthy individuals without any history of trauma. Functional connectivity within the fear circuitry, which consists of the dorsal anterior cingulate cortex, insula, amygdala, hippocampus and ventromedial prefrontal cortex (vmPFC), was examined using resting-state functional magnetic resonance imaging. Trauma-related symptoms were evaluated using the Impact of Event Scale -Revised. Results The firefighter group had greater functional connectivity between the insula and several regions of the fear circuitry including the bilateral amygdalae, bilateral hippocampi and vmPFC as compared with healthy individuals. In the firefighter group, stronger insula-amygdala connectivity was associated with greater severity of trauma-related symptoms (beta = 0.36, P = 0.005), whereas higher insula-vmPFC connectivity was related to milder symptoms in response to repeated trauma (beta = -0.28, P = 0.01). Conclusions The current findings suggest an active involvement of insular functional connectivity in response to repeated traumatic stress. Functional connectivity of the insula in relation to the amygdala and vmPFC may be potential pathways that underlie the risk for and resilience to repeated traumatic stress, respectively.

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