A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties
- 주제(키워드) Computational biology , Thalamus , Sensory gating , T-Type Calcium Channels
- 주제(기타) Medicine, Research & Experimental
- 주제(기타) Neurosciences
- 설명문(일반) [Park, Sanggeon; Sohn, Jeong-Woo; Cho, Jeiwon; Huh, Yeowool] Catholic Kwandong Univ, Coll Med, Dept Med Sci, Kangnung 25601, South Korea; [Park, Sanggeon; Sohn, Jeong-Woo; Cho, Jeiwon; Huh, Yeowool] Catholic Kwandong Univ, Translat Brain Res Ctr, Int St Marys Hosp, Incheon 22711, South Korea; [Park, Sanggeon] Univ Sci & Technol, Dept Neurosci, Daejeon 34113, South Korea; [Park, Sanggeon] Korea Inst Sci & Technol, Ctr Neurosci, Seoul 02792, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000172041
- 본문언어 영어
- Published As https://dx.doi.org/10.5607/en.2019.28.5.568
초록/요약
The thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency burst firing and single spike tonic firing has been implicated to have a key role in sensory modulation including pain. Of the two firing modes, burst firing, especially maintaining certain burst firing properties, was suggested to be critical in controlling nociceptive behaviors. Therefore, understanding the factors that influence burst firing properties would offer important insight into understanding sensory modulation. Using computational modeling, we investigated how the balance of excitatory and inhibitory inputs into a TC neuron influence TC bursting properties. We found that intensity of inhibitory inputs and the timing of excitatory input delivery control the dynamics of bursting properties. Then, to reflect a more realistic model, excitatory inputs delivered at different dendritic locations proximal, intermediate, or distal-of a TC neuron were also investigated. Interestingly excitatory input delivered into a distal dendrite, despite the furthest distance, had the strongest influence in shaping burst firing properties. suggesting that not all inputs equally contribute to modulating TC bursting properties. Overall, the results provide computational insights in understanding the detailed mechanism of the factors influencing temporal pattern of thalamic bursts.
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