Pkconverter: R package to convert the pharmacokinetic parameters
- 주제(키워드) Pharmacokinetic model , Pharmacokinetic parameter , Population analysis , R , Shiny
- 등재 SCOPUS, KCI등재
- 발행기관 Korean Society Clinical Pharmacology and Therapeutics
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172141
- 본문언어 영어
- Published As https://dx.doi.org/10.12793/tcp.2019.27.2.73
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously. © 2019 Translational and Clinical Pharmacology.
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