Dry eye syndrome and morphological changes of meibomian glands in type 2 diabetic patients
- 주제(키워드) Diabetic retinopathy , Dry eye syndrome , Meibomian gland
- 등재 SCOPUS, KCI등재
- 발행기관 Korean Ophthalmological Society (KOS)
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172193
- 본문언어 한국어
- Published As https://dx.doi.org/10.3341/jkos.2019.60.11.1037
초록/요약
Purpose: To evaluate the morphological changes of meibomian glands and dry eye syndrome in patients with type II diabetes. Methods: The medical records of 72 diabetic patients referred to the ophthalmology clinic for the evaluation of diabetic retinopathy, who had dry eye symptoms, were retrospectively reviewed. Results: A total of 72 patients, with an age of 56.3 ± 13.3 years, were analyzed. The group with diabetic retinopathy (52 patients) had a significantly lower tear film break-up time (p = 0.046), lower Schirmer’s test value (p = 0.005), and higher percentage of upper (p = 0.036) and lower (p = 0.017) meibomian gland area losses than the group without diabetic retinopathy (20 patients). According to multilinear regression analyses considering sex, age, and diabetes-related characteristics, the Schirmer’s test value was significantly lower with increasing stage of diabetic retinopathy (β = -1.180, p = 0.016). The percentage of upper meibomian gland area loss was significantly increased with increasing age (β = 0.605, p < 0.001), glycosylated hemoglobin (β = 1.881, p = 0.011), and stage of diabetic retinopathy (β = 4.458, p = 0.001). The percentage of lower meibomian gland loss area was significantly increased with increasing age (β = 0.443, p = 0.001) and stage of diabetic retinopathy (β = 4.879, p = 0.001). Conclusions: In patients with type 2 diabetes, the more severe the diabetic retinopathy, the more likely the meibomian gland loss will occur, so careful and appropriate treatment should be conducted. © 2019 The Korean Ophthalmological Society.
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