Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
- 주제(키워드) Cancer Systems Biology , Genomics , Immunology
- 등재 SCOPUS
- 발행기관 Elsevier Inc.
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172278
- 본문언어 영어
- Published As https://dx.doi.org/10.1016/j.isci.2020.101386
초록/요약
Immunology; Cancer Systems Biology; Genomics © 2020 The AuthorsExome and transcriptome analyses of clinically homogeneous early-stage never-smoker female patients with lung adenocarcinoma were performed to understand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, developing a method for effective selection of rare immune checkpoint blockade responders, and finding new treatment strategies. © 2020 The Authors
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