Effects ofKCNMB2gene polymorphisms on ritodrine therapy outcomes in women with preterm labor
- 주제(키워드) adverse drug event , KCNMB2 , preterm labor , ritodrine , single nucleotide polymorphism , time to delivery
- 주제(기타) Biotechnology & Applied Microbiology
- 주제(기타) Genetics & Heredity
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Yoon, Ha Young; Park, Jin Young; Yee, Jeong; Gwak, Hye Sun] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Yoon, Ha Young; Gwak, Hye Sun] Ewha Womans Univ, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Park, Jin Young; Yee, Jeong] Ewha Womans Univ, Div Life & Pharmaceut Sci, Seoul, South Korea; [Hwang, Han Sung] Konkuk Univ, Sch Med, Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; [Chung, Jee Eun] Hanyang Univ, Coll Pharm, Ansan, South Korea; [Chung, Jee Eun] Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan, South Korea; [Lee, Kyung Eun] Chungbuk Natl Univ, Coll Pharm, Chengju, Chungbuk, South Korea; [Kim, Young Ju] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 LIPPINCOTT WILLIAMS & WILKINS
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172345
- 본문언어 영어
- Published As https://dx.doi.org/10.1097/FPC.0000000000000404
- PubMed https://pubmed.ncbi.nlm.nih.gov/32371615
초록/요약
Objective The present prospective follow-up study aimed to evaluate the effects ofKCNMB2gene polymorphisms on ritodrine efficacy and adverse drug events (ADEs) in patients with preterm labor. Methods A total of 163 preterm labor patients were included in this single-center study. Nine single nucleotide polymorphisms (SNPs) in theKCNMB2gene (rs10936979, rs7624046, rs7429015, rs7625907, rs6443559, rs9839376, rs9637454, rs11918114, and rs1382045) were assessed. The primary endpoint was time to delivery, and the secondary endpoint was ritodrine-induced ADEs. Results Patients with variant homozygotes of two SNPs (rs7624046 and rs9839376), which were in linkage disequilibrium, showed 2.06 [95% confidence interval (CI), 1.14-3.73] and 2.68 (95% CI, 1.16-6.20) times the hazard of time to delivery compared to wild-type allele carriers, respectively. Among demographic characteristics, gestational age at start of drug therapy and modified Bishop score were significant factors for time to delivery. Regarding safety outcomes, patients with variant homozygotes of rs7625907 had fewer ADEs compared to those with other genotypes (odds ratio, 0.32; 95% CI, 0.13-0.83). Conclusion This pharmacogenomic study suggests that ritodrine efficacy and ADEs are associated withKCNMB2gene polymorphisms in patients with preterm labor.
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