Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective cohort study (KCSG HN13-01)
- 주제(키워드) Locally advanced head and neck cancer , Squamous cell carcinoma , Multidisciplinary treatment , Strategy
- 주제(기타) Oncology
- 설명문(일반) [Lee, Yun-Gyoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul, South Korea; [Kang, Eun Joo] Korea Univ, Dept Internal Med, Guro Hosp, Seoul, South Korea; [Keam, Bhumsuk] Seoul Natl Univ Hosp, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea; [Choi, Jin-Hyuk] Ajou Univ Hosp, Dept Hematol Oncol, Suwon, South Korea; [Kim, Jin-Soo] SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; [Park, Keon Uk] Keimyung Univ, Dept Hematooncol, Dongsan Med Ctr, Daegu, South Korea; [Lee, Kyoung Eun] Ewha Womans Univ Hosp, Dept Hematol & Oncol, Seoul, South Korea; [Kwon, Jung Hye] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Lee, Keun-Wook] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; [Kim, Min Kyoung] Yeungnam Univ, Dept Hematol Oncol, Med Ctr, Daegu, South Korea; [Ahn, Hee Kyung] Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; [Shin, Seong Hoon] Kosin Univ, Dept Internal Med, Gospel Hosp, Busan, South Korea; [Kim, Hye Ryun] Yonsei Univ, Yonsei Canc Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Sung-Bae] Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; [Yun, Hwan Jung] Chungnam Natl Univ Hosp, Dept Internal Med, 282 Munhwa Ro, Daejeon 35015, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 BMC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174508
- 본문언어 영어
- Published As http://dx.doi.org/10.1186/s12885-020-07297-z
- PubMed https://pubmed.ncbi.nlm.nih.gov/32854649
초록/요약
BackgroundBy investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicians in real-world practice.MethodsThis is a multi-institutional study enrolled the patients with stage III to IVB LA-HNSCC, except for nasopharyngeal carcinoma, from 2004 to 2015 in thirteen referral hospitals capable of multidisciplinary care.ResultsA total of 445 LA-HNSCC patients were analyzed. The median age was 61years (range, 24-89). The primary tumor location was the oropharynx in 191 (43%), oral cavity in 106 (24%), hypopharynx in 64 (14%), larynx in 57 (13%) and other sites in 27 (6%). The most common stage was T2 in 172 (39%), and N2 in 245 (55%). Based on treatment intents, 229 (52%) of the patients received definitive concurrent chemoradiotherapy (CCRT) and 187 (42%) underwent surgery. Approximately 158 (36%) of the study population received induction chemotherapy (IC). Taken together, 385 (87%) of the patients underwent combined therapeutic modalities. The regimen for definitive CCRT was weekly cisplatin in 58%, 3-weekly cisplatin in 28% and cetuximab in 3%. The preferred regimen for IC was docetaxel with cisplatin in 49%, and docetaxel, cisplatin plus fluorouracil in 27%. With a median follow-up of 39months, one-year and two-year survival rates were 89 and 80%, respectively. Overall survival was not significantly different between CCRT and surgery group (p=0.620).ConclusionsIn patients with LA-HNSCC, the majority of patients received combined therapeutic modalities. Definitive CCRT, IC then definitive CCRT, and surgery followed by adjuvant CCRT or radiotherapy are the preferred multidisciplinary strategies in real-world practice.
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