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Alcohol Use Disorders and Increased Risk of Adverse Birth Complications and Outcomes: An 11-Year Nationwide Cohort Study

  • 주제(키워드) preterm birth , prenatal alcohol exposure , birth complications
  • 주제(기타) Environmental Sciences
  • 주제(기타) Public, Environmental & Occupational Health
  • 설명문(일반) [Oh, Sarah Soyeon; Jee, Yongho; Kim, Young Ju] EwhaWomans Univ, Ewha Mokdong Hosp, Fetal Alcohol Syndrome Prevent Ctr, Seoul 07985, South Korea; [Oh, Sarah Soyeon; Kim, Young Ju] Ewha Womans Univ, Dept Obstet & Gynecol, Seoul 07985, South Korea; [Jee, Yongho] Ewha Womans Univ, Seoul Hosp, Adv Biomed Inst, Seoul 07985, South Korea; [Park, Eun-Cheol] Yonsei Univ, Dept Prevent Med, Seoul 03722, South Korea; [Park, Eun-Cheol] Yonsei Univ, Inst Hlth Serv Res, Seoul 03722, South Korea
  • 등재 SCIE, SSCI, SCOPUS
  • OA유형 Green Published, gold
  • 발행기관 MDPI
  • 발행년도 2020
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000175154
  • 본문언어 영어
  • Published As http://dx.doi.org/10.3390/ijerph17228515
  • PubMed https://pubmed.ncbi.nlm.nih.gov/33213014

초록/요약

For women who suffer from Alcohol Use Disorders (AUDs), the use of alcohol before and/or during pregnancy may result in various birth complications, including miscarriage, stillbirth, or preterm delivery. Thus, this study aimed to explore whether Alcohol Use Disorders (AUDs) are associated with increased risk of adverse birth complications and outcomes. A total of 76,799 deliveries between 2003 and 2013 in the Korean National Health Insurance Service National Sample Cohort (NHIS-NSC) were analyzed. Women with an AUD diagnosis preceding delivery were identified as individuals with alcohol dependence. A multivariate Cox proportional hazards model was used to estimate the hazard ratio of adverse birth complications and outcomes associated with alcohol dependence. Diagnosis of an AUD was associated with increased risk of adverse birth complications (Hazard Ratio [HR]: 1.15, 95% CI: 1.01-1.31, p = 0.0302). This was especially the case for women whose AUD diagnosis was in the same year as their delivery (HR: 1.53, 95% CI: 1.24-1.88, p < 0.0001). AUDs were associated with increased risk of adverse birth outcomes, especially when prevalent in the same year as a woman's delivery. Our study confirms that the monitoring of expecting women with a diagnosis of alcohol-related problems may be useful in preventing adverse birth complications.

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