Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation
- 주제(키워드) fetal programming , food restriction , high fat diet , taurine , HNF4A methylation
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Du, Ji Eun; You, Young Ah; Kwon, Eun Jin; Kim, Soo Min; Kim, Young Ju] Ewha Womans Univ, Coll Med, Dept Obstet & Gynecol, Seoul 07985, South Korea; [Du, Ji Eun; You, Young Ah; Kwon, Eun Jin; Kim, Soo Min; Kim, Young Ju] Ewha Womans Univ, Coll Med, Ewha Med Res Inst, Seoul 07985, South Korea; [Lee, Jeongae] Korea Inst Sci & Technol, Mol Recognit Res Ctr, Seoul 02792, South Korea; [Han, Ki Hwan] Ewha Womans Univ, Coll Med, Dept Anat, Seoul 07985, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175162
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/ijms21239060
- PubMed https://pubmed.ncbi.nlm.nih.gov/33260590
초록/요약
Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet-related alterations in metabolites and the biological pathway in male offspring at three months of age. Pregnant rats were exposed to 50% food restriction during the prenatal period or a 45% high-fat diet during the prenatal and postnatal periods. The male offspring exposed to food restriction and high-fat diets had lower birth weights than controls, but had a catch-up growth spurt at three months of age. Hepatic taurine levels decreased in both groups compared to controls. The decreased hepatic taurine levels in offspring affected excessive lipid accumulation through changes in hepatocyte nuclear factor 4 A methylation. Moreover, the alteration of gluconeogenesis in offspring exposed to food restriction was observed to a similar extent as that of offspring exposed to a high fat diet. These results indicate that maternal diet affects the dysregulation in hepatic metabolism through changes in taurine levels and HNF4A methylation, and predisposes the offspring to Type 2 diabetes and non-alcoholic fatty liver disease in later life.
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