Prognostic value of left atrial volume index in patients with rheumatic mitral stenosis
- 주제(키워드) left atrium , mitral stenosis , prognosis
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 John Wiley and Sons Inc
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175361
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/clc.23544
- PubMed https://pubmed.ncbi.nlm.nih.gov/33405242
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: The significance of left atrial volume index (LAVI) for predicting outcomes in patients with mitral stenosis (MS) has been unclear, even though rheumatic MS is known to be associated with left atrium enlargement and functional deterioration. Hypothesis: The current study aimed to investigate the prognostic value of LAVI, based on the severity in patients with rheumatic MS. Methods: We retrospectively reviewed 611 patients with pure rheumatic MS. The prognostic value of LAVI and the effect of MS severity on the prognostic value of LAVI for events were evaluated. The events were defined as a composite end-point that included all-cause death, heart failure admission, mitral valve replacement, percutaneous mitral valvuloplasty, and stroke. Results: There were 236 (38.6%) overall events during a median follow-up of 8 months. The optimal LAVI cutoff for the prognostic threshold was 57 ml/m2. The MS severity had a significant effect on the prognostic value of LAVI. A LAVI >57 ml/m2 was a prognostic value for events in progressive MS (hazard ratio [HR]: 2.40, 95% confidence interval [CI]: 1.41–5.40, p =.004) and in patients with severe MS (HR: 1.70, 95% CI: 1.06–2.74, p =.029), but it was not prognostic in patients with very severe MS (HR: 1.02, 95% CI: 0.56–1.84, p =.955). Conclusions: The prognostic value of LAVI varies and is dependent on the MS severity. A LAVI >57 mL/m2 was independently associated with poor outcomes in patients with progressive MS, while this association was minimized in patients with severe MS. © 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
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