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Antihypertensive Drugs and the Risk of Cancer: A Nationwide Cohort Study

  • 주제(키워드) antihypertensive agent , neoplasms , cohort study
  • 주제(기타) Medicine, General & Internal
  • 설명문(일반) [Cho, In-Jeong; Pyun, Wook Bum] Ewha Womans Univ, Ewha Womans Univ Seoul Hosp, Div Cardiol, Dept Internal Med,Coll Med, Seoul 07985, South Korea; [Shin, Jeong-Hun; Kim, Woohyeun; Shin, Jinho] Hanyang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul 04763, South Korea; [Jung, Mi-Hyang] Hallym Univ, Dongtan Sacred Heart Hosp, Cardiovasc Ctr, Coll Med, Hwaseong 18450, South Korea; [Kang, Chae Young; Hwang, Jinseub] Daegu Univ, Dept Stat & Comp Sci, Gyongsan 38453, South Korea; [Kwon, Chang Hee] Konkuk Univ, Med Ctr, Div Cardiol, Dept Internal Med,Sch Med, Seoul 05030, South Korea; [Kim, Dae-Hee] Univ Ulsan, Div Cardiol, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; [Lee, Chan Joo; Cho, Iksung; Park, Sungha; Kang, Seok-Min] Yonsei Univ, Severance Cardiovasc Hosp, Div Cardiol, Coll Med, Seoul 03722, South Korea; [Lee, Chan Joo; Cho, Iksung; Park, Sungha; Kang, Seok-Min] Yonsei Univ, Cardiovasc Res Inst, Coll Med, Seoul 03722, South Korea; [Kang, Si-Hyuck; Kim, Kwang Il] Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam Si 13620, South Korea; [Lee, Ju-Hee; Cho, Myeong-Chan] Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Div Cardiol, Dept Internal Med,Coll Med, Cheongju 28644, South Korea; [Kim, Hack-Lyoung] Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Coll Med, Seoul 07061, South Korea; [Kim, Hyue Mee] Chung Ang Univ Hosp, Div Cardiol, Dept Internal Med, Seoul 06973, South Korea; [Lee, Hae-Young] Seoul Natl Univ Hosp, Div Cardiol, Dept Internal Med, Seoul 03080, South Korea; [Chung, Wook-Jin] Gachon Univ, Dept Cardiovasc Med, Gil Med Ctr, Incheon 21565, South Korea; [Ihm, Sang-Hyun] Catholic Univ Korea, Bucheon St Marys Hosp, Div Cardiol, Dept Internal Med, Bucheon Si 14647, South Korea; [Cho, Eun Joo] Catholic Univ Korea, Yeouido St Marys Hosp, Div Cardiol, Dept Internal Med, Seoul 07345, South Korea; [Sohn, Il-Suk] Kyung Hee Univ Gangdong, Div Cardiol, Dept Internal Med, Seoul 05278, South Korea; [Ryu, Sung Kee] Eulji Med Sch Med, Div Cardiol, Dept Internal Med, Seoul 01830, South Korea; [Kim, Jang Young] Yonsei Univ, Wonju Coll Med, Div Cardiol, Dept Internal Med, Wonju 26426, South Korea; [Sung, Ki-Chul] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Cardiol, Dept Internal Med,Sch Med, Seoul 03181, South Korea
  • 등재 SCIE, SCOPUS
  • 발행기관 MDPI
  • 발행년도 2021
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000181478
  • 본문언어 영어
  • Published As http://dx.doi.org/10.3390/jcm10040771

초록/요약

We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-converting enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696-0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775-0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was independently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.

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